Cortisol, released in response to stress, is mainly produced by theadrenal cortex. Intra-abdominal adipocytes also produce cortisol. In arecent study, Sensoril^®ashwagandha extract promoted relaxation andmaintained healthy cortisol and C-reactive protein levels. Subjects in thisrandomized, double blind, placebo-controlled study reported support forhealthy sleep, positive mood and cognitive function. The effects weremost pronounced for subjects taking 500 mg per day compared to lesserdoses. Rhodiola and magnolia may also maintain healthy adrenal cortisolactivity and offer support for stress, mood and emotional well-being.l-Theanine supports normal brain alpha-wave activity, helping calmthe sympathetic nervous system for a relaxing effect. Recent researchsuggests that maintaining healthy vitamin D levels supports normalcortisol production within abdominal adipocytes.