√ Functions as a donor of methyl groups in over 100 different reactions catalyzed by methyltransferase enzymes, as well as a precursor molecule for glutathione and polyamine synthesis*

√ Supports positive mood and cognitive function*

• In a meta-analysis involving 25 controlled trials and 791 individuals, SAMe offered statistically significant support for positive mood*
• Promotes healthy protein turnover to support healthy CNS function*
• Maintains healthy phospholipid methylation to support phosphatidylcholine production and cellular membrane integrity and fluidity*
• Supports neurotransmitter monoamine synthesis and function, including dopamine and serotonin, through SAMe-dependent methylation reactions*

√ Promotes liver function by supporting glutathione production*

• Clinical trials indicate that SAMe administration enhances glutathione production in hepatic tissue and red blood cells*

√ Enhances joint comfort by supporting proteoglycan synthesis, as well as helping to stabilize and protect proteoglycans*

• In a 16-week randomized, double-blind, placebo-controlled trial involving 56 subjects, SAMe offered statistically significant support for joint comfort*

√ Maintains healthy cell growth and cytokine balance by supporting healthy polyamine production*